RNA Details
Disease Name
myocardial infarction
Tissue
heart
RNA Symbol
Klf5
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
bioinformatic analyses;luciferase assays
Target
mir-27a
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Promoting roles of KLF5 in myocardial infarction in mice involving microRNA-27a suppression and the following GFPT2/TGF-beta/Smad2/3 axis activation
Year
2021
Function
KLF5 possibly induces cell and tissue damage in myocardial infarction through downregulation of miR-27a and the subsequent activation of GFPT2/TGF-beta/Smad2/3 axis.